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THE HEPATIC TRANSPORT OF TAUROCHOLIC ACID IN THE RAT: DEVELOPMENT OF A MATHEMATICAL MODEL
Author(s) -
Iser J. H.,
Packer J. S.,
Smallwood R. A.,
Hoffman N. E.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00588.x
Subject(s) - taurocholic acid , chemistry , biochemistry , bile acid
SUMMARY 1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabeled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The secretory profile was little modified by a 500‐fold increase in the injected dose. 4. The transport process was modelled with both analogue and digital computers. The simplest model which fitted the data comprised rapid uptake from portal blood, slow transport across the cell and rapid secretion into bile. The digital computer simulation suggested that this model is not unique, but will require further testing.