Premium
Pressure‐flow relationships in the peripheral circulation of the dog with practolol
Author(s) -
Green Jerry Franklin,
Moore John D.,
Attix Edward S.,
Zelis Robert
Publication year - 1975
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1975.tb02369.x
Subject(s) - practolol , peripheral , peripheral resistance , venous return curve , antagonist , medicine , vascular resistance , cardiology , central venous pressure , anesthesia , blood pressure , hemodynamics , cardiac output , heart rate , receptor , propranolol
SUMMARY 1. The influence of practolol (a proposed β 1 ‐adrenoreceptor antagonist) upon the pressure‐flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by‐pass procedures. 2. Practolol (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective β‐adrenoreceptor antagonist.