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The cardiovascular effects of intraventricular 5,6‐dihydroxytryptamine in conscious hypertensive rats
Author(s) -
Finch L.
Publication year - 1975
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1975.tb01855.x
Subject(s) - methysergide , phentolamine , serotonergic , microgram , medicine , blood pressure , bradycardia , endocrinology , 5,7 dihydroxytryptamine , anesthesia , chemistry , serotonin , heart rate , propranolol , receptor , biochemistry , in vitro
SUMMARY 1. Conscious experimental hypertensive rats injected intraventricularly with 5,6‐dihydroxytryptamine (50 μg) responded with a rapid and long‐lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6‐dihydroxytryptamine on the cardiovascular system were not modified by pretreatment with bromolysergide (0·5 mg/kg, i.p.), methysergide (2·5 mg/kg, i.p.) or intraventricular phentolamine (200 μg). 3. The results suggest that central serotonergic neurones play an important role in the regulation of blood pressure. However, the site of action remains to be investigated.