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Some pharmacological effects of δ‐aminolaevulinic acid on blood pressure in the rat and on rabbit isolated ear arteries
Author(s) -
McGillion F. B.,
Moore M. R.,
Goldberg A.
Publication year - 1975
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1975.tb01844.x
Subject(s) - phentolamine , hexamethonium , medicine , mepyramine , endocrinology , perfusion , vasopressin , blood pressure , pressor response , atropine , epinephrine , chemistry , vasoconstrictor agents , norepinephrine , stimulation , heart rate , antagonist , receptor , dopamine
SUMMARY 1. The effects of δ‐aminolaevulinic acid (ALA) have been examined on the blood pressure of anaesthetized rats and pithed rats and on the perfusion pressure in isolated preparations of the rabbit ear artery. 2. ALA has a hypotensive effect in both anaesthetized and pithed rats. 3. In anaesthetized rats, the hypotensive response was produced with either continuous infusion or single injections of ALA, and was not blocked by hexamethonium, propanolol, phentolamine, atropine or mepyramine. 4. In the pithed rat, ALA had no effect on the pressor response to nicotine. 5. The hypotensive response to ALA could be counteracted by the pressor effect of adrenaline or noradrenaline. In pithed rats, the pressor response of vasopressin was reduced by ALA. 6. Vasoconstrictor response of the isolated perfused rabbit ear artery to noradrenaline and sympathetic nerve stimulation were usually not affected by ALA, but in a few experiments they were increased. ALA produced an increase in perfusion pressure in a few experiments. 7. Since ALA appears to cause an increase in capillary permeability, it is probable that the hypotensive effect is associated with capillary dilatation.