Premium
Pressure‐flow relationships in the peripheral circulation of the dog with isoprenaline
Author(s) -
Green Jerry Franklin
Publication year - 1975
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1975.tb01833.x
Subject(s) - isoprenaline , venous return curve , peripheral resistance , venous pressure , peripheral , medicine , cardiac output , cardiology , central venous pressure , vascular resistance , hemodynamics , blood pressure , anesthesia , heart rate , stimulation
SUMMARY 1. The effects of isoprenaline on the pressure‐flow relationships in the peripheral circulation were studied in five anaesthetized dogs during right heart bypass procedures. 2. Isoprenaline (1 μg/kg per min) produced a significant drop in arterial pressure and arterial resistance. 3. There was a significant decrease in the resistance to venous return which resulted in a significant increase in venous return. 4. The findings suggest that the increase in cardiac output produced by isoprenaline results in large part from dilatation of venous resistance vessels.