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DISAPPEARANCE RATE OF CIRCULATING RENIN AFTER BILATERAL NEPHRECTOMY IN THE RAT
Author(s) -
Oates Helen F.,
Fretten Julie A.,
Stokes Gordon S.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00576.x
Subject(s) - nephrectomy , plasma renin activity , renin–angiotensin system , medicine , endocrinology , bilateral nephrectomy , endogeny , kidney , blood pressure
SUMMARY 1. Plasma renin concentration (PRC) was measured in eight male rats at intervals during a 6 h period after bilateral nephrectomy. 2. PRC fell rapidly, reaching 51% of the mean control level by 10 min, 29% by 30 min, and 2% by 4 h. 3. Under the conditions of the experiment, the half‐life of circulating endogenous renin in the rat was about 10 min.