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THE HEPATIC TRANSPORT OF SODIUM TAUROCHOLATE IN THE RAT: EFFECT OF PHENOBARBITONE
Author(s) -
Iser J. H.,
McClelland M. J.,
Stening G. F.,
Smallwood R. A.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00575.x
Subject(s) - chemistry , phenobarbital , pharmacology , sodium , medicine , organic chemistry
SUMMARY 1. The effect of pretreatment with phenobarbitone on the hepatic transport of sodium 14 C‐taurocholate was studied in the Sprague Dawley rat. Taurocholate solutions were injected into the portal vein in a volume of 0.2 ml in 2 s. 2. Biliary secretion of taurocholate injected into the portal vein in a concentration of 25 μM was not altered by pretreatment with phenobarbitone. This concentration of taurocholate corresponds to that occurring normally in portal venous blood. 3. When taurocholate was injected in a much larger concentration (13 mM), biliary secretion of taurocholate was significantly slower in phenobarbitone‐pretreated rats than in control rats. 4. Changes in hepatic bile salt transport do not appear to contribute to the choleresis that occurs with phenobarbitone.