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THE EFFECTS OF KININS AND THEIR INTERACTIONS WITH ADRENERGIC MECHANISMS ON THE BEHAVIOURAL ACTIVITY OF RATS
Author(s) -
Wiśniewski K.,
MoniuszkoJakoniuk J.,
Sosnowska Z.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00572.x
Subject(s) - nialamide , reserpine , bradykinin , medicine , endocrinology , kallikrein , chemistry , adrenergic , kinin , tetrabenazine , dopamine , receptor , biochemistry , enzyme
SUMMARY 1. Intraperitoneal administration of kallikrein (50 u/kg) to rats increased the kinin‐forming activity of the brain but had no effect on behaviour. 2. Injection of bradykinin (1 μg) into a cerebral ventricle slightly decreased the behavioural activity of rats. 3. The increase in activity produced by pretreatment with nialamide (200 mg/kg) was greatly potentiated by administration of kallikrein or bradykinin in the doses and by the routes mentioned above. 4. Injection of noradrenaline (50 μg) into a cerebral ventricle had no effect on activity in normal rats and slightly increased the activity of rats pretreated with reserpine. 5. When noradrenaline was given with kallikrein or bradykinin, activity was markedly increased in normal and reserpinized rats. 6. The results suggest that kinins may influence central neurotransmission.