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METOCLOPRAMIDE AS A DOPAMINE ANTAGONIST IN THE HEART AND GUT OF THE MOLLUSC TAPES WATLINGI
Author(s) -
Dougan D. F. H.,
Mearrick P. T.,
Wade D. N.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00568.x
Subject(s) - metoclopramide , dopamine , antagonist , dopamine antagonist , levodopa , dopamine receptor , blockade , medicine , catecholamine , pharmacology , endocrinology , anesthesia , receptor , parkinson's disease , disease , vomiting
SUMMARY 1. Metoclopramide is a potent antagonist of the inhibitory response to dopamine in two isolated tissues, the electrically stimulated intestine and the spontaneous beating heart, from the mollusc Tapes watlingi. 2. Blockade by metoclopramide of dopamine receptors in the central nervous system of man may account for the relapse of patients with Parkinson's disease which occurs when metoclopramide is given during successful therapy with levodopa.