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DISPOSITION OF SEROTONIN IN THE RAT BLOOD VESSELS AND HEART
Author(s) -
Berkowitz B. A.,
Lee C.H.,
Spector S.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00561.x
Subject(s) - pargyline , serotonin , monoamine oxidase , monoamine oxidase inhibitor , medicine , endocrinology , disposition , chemistry , pharmacology , enzyme , biochemistry , receptor , psychology , social psychology
SUMMARY 1. Serotonin is present in blood vessels and the heart of the rat in concentrations of about one‐sixth that of noradrenaline. 2. The concentrations of serotonin are increased two‐fold following treatment with the monoamine oxidase inhibitor, pargyline, and the elevation of levels is rapid. 3. It is suggested that monoamine oxidase regulates the content of serotonin in blood vessels and the heart.