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INHIBITION OF RENIN‐ANGIOTENSIN INDUCED DRINKING IN THE CAT BY ENZYME INHIBITORS AND BY ANALOGUE ANTAGONISTS OF ANGIOTENSIN II
Author(s) -
Cooling M. J.,
Day M. D.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00560.x
Subject(s) - renin–angiotensin system , angiotensin ii , medicine , endocrinology , angiotensin iii , chemistry , angiotensin converting enzyme , antagonist , angiotensin ii receptor type 1 , angiotensin receptor , receptor , blood pressure
SUMMARY 1. Intracerebroventricular (icv) administration of the renin inhibitor pepstatin inhibited the dipsogenic response to icv renin but did not affect drinking induced by icv angiotensin I and II. 2. Intracerebroventricular administration of an angiotensin converting enzyme inhibitor, SQ 20881, reduced the dipsogenic effect of icv renin and angiotensin I but did not affect angiotensin II induced drinking. 3. Intracerebroventricular administration of SQ 20881 reduced the dipsogenic effect of intravenous angiotensin I but did not reduce drinking elicited by intravenous angiotensin II. 4. Intracerebroventricular administration of Sar 1 ‐Ala 8 ‐angiotensin II, a competitive antagonist of angiotensin II, inhibited drinking elicited by icv renin, angiotensin I and angiotensin II. The dipsogenic response to intravenous infusion of both angiotensins I and II was reduced after central administration of this antagonist. 5. Four analogue antagonists of angiotensin II given icv reversibly inhibited the dipsogenic response to icv angiotensin II. These analogues themselves possessed weak dipsogenic effects. 6. Renin‐angiotensin induced drinking in the cat is mediated by the action of angiotensin II on receptors in the central nervous system.