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EFFECTS OF P ‐CHLOROPHENYLALANINE ON BLOOD PRESSURE AND HEART RATE IN NORMAL RABBITS AND RABBITS WITH NEUROGENIC HYPERTENSION
Author(s) -
Wing L. M. H.,
Chalmers J. P.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00544.x
Subject(s) - heart rate , blood pressure , medicine , serotonin , intraperitoneal injection , endocrinology , anesthesia , tachycardia , receptor
SUMMARY 1. Intraperitoneal administration of p ‐chlorophenylalanine ( p CPA: 100–400 mg/kg per day) reduced central serotonin concentrations to 20–50% of control in the rabbit. 2. Intraperitoneal administration of a single dose of p CPA (400 mg/kg) decreased heart rate by 14% for a period of 1–2 days, but did not affect arterial pressure. 3. Repeated intraperitoneal administration of p CPA (100 mg/kg per day) caused a gradual reduction in arterial pressure to about 90% of control values over a 10 day period, but had no consistent effect on heart rate. 4. In rabbits that received repeated intraperitoneal injections of p CPA (100 mg/kg per day), the tachycardia that followed sinoaortic denervation was not as well sustained as in normal rabbits; the development of neurogenic hypertension was unaltered. 5. Intracisternal administration of p CPA was particularly toxic in the rabbit; the maximum doses tolerated did not succeed in lowering central serotonin concentration and had no effect on blood pressure or heart rate.