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USE OF CUMULATIVE DOSE‐RESPONSE CURVES IN POTENCY COMPARISONS OF SYMPATHOMIMETIC AMINES ON PULMONARY RESISTANCE IN ANAESTHETIZED CATS
Author(s) -
Rodger I. W.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00543.x
Subject(s) - salbutamol , potency , bronchoconstriction , bronchodilator , sympathomimetics , cats , anesthesia , medicine , bronchodilator agents , pharmacology , cumulative dose , chemistry , asthma , airway , biochemistry , in vitro
SUMMARY 1. A method for assessing the bronchodilator potency of sympathomimetics in anaesthetized cats is described. 2. The bronchodilator actions of laevoisoprenaline, rimiterol and salbutamol, administered by cumulative intravenous injection, were assessed against bronchoconstriction produced by an intravenous infusion of serotonin. Rimiterol and salbutamol, by weight, were each about eight times less potent than laevoisoprenaline. 3. The method allows the construction of reproducible dose‐response curves. It is relatively quick, and is especially useful when assessing the potencies of long‐acting sympathomimetic bronchodilators.