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A novel sequence in kangaroo angiotensin I
Author(s) -
Best J. B.,
BlairWest J. R.,
Coghlan J. P.,
Cran E. J.,
Fernley R. T.,
Simpson P. A.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00539.x
Subject(s) - radioimmunoassay , renin–angiotensin system , angiotensin ii , medicine , endocrinology , chemistry , biology , blood pressure
SUMMARY 1. The incubation of kangaroo renin‐substrate with renin from kangaroo, hog or sheep yields angiotensin having pressor activity in the rat. 2. Kangaroo angiotensin I is not reactive in radioimmunoassay which is sensitive to other forms of angiotensin I. 3. Kangaroo angiotensin I is converted by passage through the rat pulmonary circulation or by equine converting enzyme to a reactive product in radioimmunoassay for angiotensin II. 4. The findings suggest that the amino acid sequence of kangaroo angiotensin I differs from that of other known angiotensins.