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THE RENIN‐ALDOSTERONE SYSTEMS IN THE PREGNANT RHESUS MONKEY ( MACACA MULATTA )
Author(s) -
Wintour E. Marelyn,
Knobil E.,
Scoggins B. A.,
Skinner S. L.,
Coghlan J. P.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00538.x
Subject(s) - aldosterone , endocrinology , medicine , corticosterone , plasma renin activity , renin–angiotensin system , hormone , significant difference , pregnancy , chemistry , biology , blood pressure , genetics
SUMMARY 1. The concentrations of aldosterone, corticosterone, cortisol and renin substrate in plasma and the plasma renin activity were determined in five non‐pregnant and five pregnant rhesus monkeys. 2. The mean aldosterone concentrations are 25.9 ng/100 ml in the non‐pregnant and 31.4 ng/100 ml in the pregnant monkey: the difference is not significant ( P >0.5). 3. The mean corticosterone concentrations are 1.11 and 1.84 μg/100 ml respectively: the difference is not significant ( P >0.1). 4. The mean cortisol concentrations are 21.3 and 28.2 μg/100 ml respectively: the difference is significant ( P <0.05). 5. Pregnancy does not result in increases in either plasma renin activity, mean values being 4.96 and 3.72 ng/ml per h, respectively, or renin substrate concentrations, the means being 1.09 and 0.82 μg/ml, respectively. 6. The lack of elevation of these hormones is consistent with findings that concentrations of progesterone and oestrogen are only slightly increased in pregnancy in rhesus monkeys.