Premium
PLASMA RENIN RESPONSE TO ACUTE BLOCKADE OF ANGIOTENSIN II IN THE ANAESTHETIZED RAT
Author(s) -
Oates Helen F.,
Stokes Gordon S.,
Glover Robyn G.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00536.x
Subject(s) - renin–angiotensin system , plasma renin activity , medicine , saline , blockade , endocrinology , angiotensin ii , chemistry , blood pressure , antagonist , endogeny , receptor
SUMMARY 1. Anaesthetized rats were infused intravenously for 1 h with a specific antagonist of angiotensin II, 1‐Sar‐8‐Ala‐angiotensin II (P‐113), at a rate of 5 μ/kg per min, or with saline. 2. Blood samples were taken, before and after infusion, for measurement of plasma renin activity (PRA) and plasma renin concentration (PRC). 3. Saline infusion did not affect PRA or PRC. 4. Infusion of P‐113 produced steep and highly significant increases in PRA (652%) and PRC (724%), despite a slight rise in mean arterial pressure. 5. Within 30 min of terminating P‐113 infusion, PRA fell to 300%, and PRC to 278% of pre‐infusion levels, and subsequently continued to fall. 6. It is suggested that the hypersecretion of renin produced by P‐113 is due to blockade of the inhibitory control normally exerted by endogenous angiotensin II on renin release.