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VISUAL EVOKED POTENTIALS AS A MEASURE OF DRUG EFFECTS ON AROUSAL IN THE RABBIT
Author(s) -
Goldberg H.,
Horvath T. B.,
Meares R. A.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00535.x
Subject(s) - arousal , stimulant , sedative , scalp , evoked potential , stimulus (psychology) , visual evoked potentials , anesthesia , electroencephalography , audiology , psychology , medicine , pharmacology , neuroscience , anatomy , cognitive psychology
SUMMARY 1. Averaged evoked potentials in response to light flashes were recorded from the scalp in conscious, restrained rabbits. Six sedative and three stimulant drugs were administered intravenously and their effects on the evoked potential were measured 2. All six sedative drugs reduced the amplitude of the surface‐negative wave occurring 150–200 ms after the stimulus, whereas all three stimulants increased the size of this component. No such consistency was found in drug effects on the early surface‐positive wave. 3. The results obtained support the hypothesis that the size of certain components of sensory averaged evoked potentials is related to the level of behavioural arousal.