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POTENTIATION OF AN EFFECT OF ALLOPURINOL ON PYRIMIDINE METABOLISM BY CHLOROTHIAZIDE IN MAN
Author(s) -
Wood Margaret H.,
O'Sullivan W. J.,
Wilson M.,
Tiller D. J.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00526.x
Subject(s) - allopurinol , chlorothiazide , orotic acid , chemistry , pyrimidine , pyrimidine metabolism , pharmacology , metabolism , endocrinology , biochemistry , enzyme , medicine , purine , diuretic
SUMMARY 1. Treatment with allopurinol leads to increased excretion of the pyrimidine compounds orotic acid and orotidine, and to increased levels in erythrocytes of the enzymes orotate phosphoribosyltransferase and orotidylate decarboxylase. 2. The effects of allopurinol on pyrimidine metabolism are enhanced by concurrent treatment with chlorothiazide. 3. This interaction between allopurinol and chlorothiazide does not appear to give rise to any disadvantageous effects. Knowledge of such interactions could lead to more rational drug therapy.