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A comparison of the activities of the β‐adrenoceptor agonists MJ9184–1 and (—)‐ isoprenaline in guinea‐pig and cat preparations
Author(s) -
Davey T.,
Malta E.,
Raper C.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00525.x
Subject(s) - chronotropic , isoprenaline , guinea pig , cats , pharmacology , stimulant , medicine , chemistry , endocrinology , norepinephrine , receptor , in vivo , biology , heart rate , stimulation , blood pressure , dopamine , microbiology and biotechnology
SUMMARY 1. The β‐adrenoceptor stimulants MJ9184–1 (2'‐hydroxy‐5'‐[1‐hydroxy‐2‐(2‐methyl‐1‐phenyl‐2‐propylamino)ethyl]methanesulphonanilide) and (—)‐isoprenaline have been compared for their ability to produce agonistic actions in isolated atrial and in tracheal preparations from guinea‐pigs and cats. 2. The ability of the compounds to produce cardiac chronotropic actions and to reduce serotonin‐induced increases in pulmonary resistance has been assessed in anaesthetized guinea‐pigs. The findings have been compared with those obtained previously in cats. 3. There are marked differences in the relative stimulant activity of the two compounds between tissues, between species and between in vivo and in vitro situations. 4. The results suggest that β‐adrenoceptors in cat and guinea‐pig may differ. Preparations suitable for predicting the selectivity of action of β‐receptor agonists in man are discussed.