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CARDIOVASCULAR EFFECTS OF DOPAMINE IN THE ANAESTHETIZED DOG
Author(s) -
Sampson R. G.,
Scroop G. C.,
Louis W. J.
Publication year - 1974
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1974.tb00521.x
Subject(s) - phentolamine , dopamine , dopamine receptor , dopaminergic , propranolol , medicine , heart rate , endocrinology , agonist , dopamine agonist , blood pressure , chemistry , pharmacology , receptor
SUMMARY 1. The cardiovascular actions of dopamine have been studied in the anaesthetized dog by measuring blood pressure, heart rate, cardiac output and peripheral resistance. 2. Observations with phentolamine, propranolol and haloperidol indicate that dopamine acts on α‐ and β‐adrenoreceptors, and also on specific dopamine receptors. 3. In dogs pretreated with phentolamine, dopamine has a potent vasodilator action which appears to be mediated through specific dopaminergic receptors. 4. Displacement of noradrenaline by dopamine is not an important component of the pressor response in the dog, and dopamine does not appear to act as a partial agonist in mediating the depressor response.