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A case of pemphigoid gestationis with concurrent IgG antibodies to BP 180, BP 230 and type VII collagen
Author(s) -
Yang Baoqi,
Wang Chong,
Wu Mei,
Du Donghong,
Yan Xiaoxiao,
Zhou Guizhi,
Zhang Furen
Publication year - 2014
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2012.00960.x
Subject(s) - medicine , autoantibody , pemphigoid , bullous pemphigoid , antibody , dermatology , autoimmune disease , immunofluorescence , cyclophosphamide , direct fluorescent antibody , epitope , pathology , immunology , chemotherapy
A 22‐year‐old primigravida had a pruritic, erythematous, bullous eruption on the skin during the 26th week of gestation. After delivery the eruption flared up. The diagnosis of pemphigoid gestationis was confirmed based on histopathological and immunofluorescence findings. The result of immunoblotting showed IgG autoantibodies which reacted against BP 230 in epidermal extracts and 290 kDa type VII collagen in dermal extracts. The BP 180 antibodies were also detected by an enzyme‐linked immunosorbent assay BP 180 NC16a diagnosis kit. Pulsed corticosteroid and cyclophosphamide resulted in a favourable response at the acute stage. The patient was cured in 2 years. The analysis of the patient's autoantibodies provides strong evidence for the involvement of epitope spreading in her autoimmune disease.