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Toxic epidermal necrolysis caused by over the counter eyedrops
Author(s) -
Byrom Lisa,
Zappala Tania,
Muir Jim
Publication year - 2013
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2012.00936.x
Subject(s) - toxic epidermal necrolysis , medicine , dermatology , rash , etiology , total body surface area , allergy , surgery , pathology , immunology
We present a case of a 15‐year‐old boy who developed toxic epidermal necrolysis ( TEN ) from sulfacetamide eyedrops. He presented with conjunctival injection and an erythematous rash that rapidly progressed to epidermal necrosis of over 30% of his body. A skin biopsy revealed an acute lichenoid reaction pattern consistent with TEN . After 22 days in hospital, he was left with significant scarring to his eyes, mouth and anogenital areas. An extensive search for an infective aetiology was negative. Previously exposed to b actrim tablets, he used B leph‐10 eyedrops 3 days before admission to hospital. The patient had a strong family history of sulphur allergy. The onset of TEN after topical administration of medication has been reported rarely in the literature. This case highlights the need for a thorough medication history that includes topical preparations.