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Effect of captopril on infantile haemangiomas: A retrospective case series
Author(s) -
Christou Elizabeth M,
Wargon Orli
Publication year - 2012
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2012.00901.x
Subject(s) - medicine , captopril , involution (esoterism) , corticosteroid , angiotensin converting enzyme , retrospective cohort study , lesion , endocrinology , surgery , blood pressure , politics , political science , law
The mechanism of action of beta adrenergic blockers in the involution of infantile haemangioma (IH) remains unclear. It has been proposed that the renin‐angiotensin pathway may play a role. We present a retrospective case series of 17 patients with IH who were treated with oral corticosteroid therapy and developed hypertension requiring treatment with the angiotensin converting enzyme inhibitor, captopril. All patients, with written documentation, demonstrated an improvement in their lesion at the start of oral corticosteroid therapy ( n = 14). Captopril alone did not sustain the corticosteroid‐induced involution with a documented worsening of infantile haemangioma in seven out of 12 patients (58%).