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The evaluation of the clinical effect of topical St Johns wort ( Hypericum perforatum L .) in plaque type psoriasis vulgaris: A pilot study
Author(s) -
Najafizadeh Parvaneh,
Hashemian Farshad,
Mansouri Parvin,
Farshi Susan,
Surmaghi Mohammadhossein Salehi,
Chalangari Reza
Publication year - 2012
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2012.00877.x
Subject(s) - hypericum perforatum , medicine , psoriasis area and severity index , psoriasis , erythema , dermatology , hypericum , plaque psoriasis , hyperforin , hypericin , pharmacology , traditional medicine
In this case series, ten patients with plaque‐type psoriasis were treated with Hypericum perforatum ointment. The hypericum ointment was applied to one side of each patient's body and the vehicle to the opposite side twice daily for 4 weeks in a single blinded manner. Modified psoriasis area severity index (PASI) scores were significantly lowered where the formulated ointment had been applied. In determining PASI scores, three factors, erythema, scaling and thickness, were evaluated; all were significantly lower where the formulated ointment had been applied ( P = 0.01, P = 0.004, P = 0.04). Hypericum perforatum ointment applied twice daily may be effective in reducing PASI scores in mild plaque‐type psoriasis, however, further larger studies need be conducted to achieve a more conclusive result.