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Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus
Author(s) -
Klein Annette,
Vogt Thomas,
Wenzel Sabrina M,
Fleck Martin,
Landthaler Michael
Publication year - 2011
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2010.00689.x
Subject(s) - medicine , subacute cutaneous lupus erythematosus , methotrexate , refractory (planetary science) , lupus erythematosus , dermatology , systemic lupus erythematosus , cutaneous lupus erythematosus , toxicity , immunology , connective tissue disease , autoimmune disease , disease , antibody , physics , astrobiology
ABSTRACT The treatment of subacute cutaneous lupus erythematosus is a therapeutic challenge. Frequently, patients are resistant to or intolerant towards single selected immunosuppressants. In combination, lower doses of methotrexate and cyclosporin A might be used to minimize toxicity. This is the first report of a successful combination of these drugs in two patients suffering from subacute cutaneous lupus erythematosus refractory to standard treatment.