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Dermatomyositis and pemphigus vulgaris: Association or coincidence?
Author(s) -
Black Michael,
Marshman Gillian
Publication year - 2011
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2010.00646.x
Subject(s) - medicine , dermatomyositis , pemphigus vulgaris , dermatology , prednisolone , histopathology , methotrexate , prednisone , malignancy , rash , tacrolimus , pathology , gastroenterology , surgery , transplantation
A 76‐year‐old woman presented with a pruritic photodistributed rash and dysphagia. Serum anti‐nuclear antibody was positive (titre 1/1280) and skin and muscle biopsies confirmed a diagnosis of dermatomyositis. She was treated with oral prednisolone (5–50 mg/day), mometasone furoate 0.1% ointment and lotion, and tacrolimus 0.03% ointment. Four years later she presented with multiple painful scaly erosions on the face, scalp and trunk. Histopathology and direct and indirect immunofluorescence confirmed a diagnosis of pemphigus vulgaris. Repeated malignancy screens were negative. She was treated with methotrexate (10 mg/week) and prednisolone (50 mg/day slowly tapered to 5 mg/day), with good control of both diseases.