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Erosive pustular dermatosis of the leg: Long‐term control with topical tacrolimus
Author(s) -
Dall'Olio Elena,
Rosina Paolo,
Girolomoni Giampiero
Publication year - 2011
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2009.00584.x
Subject(s) - medicine , tacrolimus , dermatology , pustulosis , scalp , clobetasol propionate , spongiosis , surgery , transplantation , psoriasis , osteomyelitis , osteitis
Erosive pustular dermatosis of the leg is an unusual form of sterile pustulosis that typically affects the lower limbs of elderly patients. We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long‐term disease control.