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Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite–Canada syndrome
Author(s) -
Ho Vincent,
Banney Leith,
Falhammar Henrik
Publication year - 2008
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2008.00474.x
Subject(s) - medicine , hyperpigmentation , dermatology , enteropathy , abnormality , skin hyperpigmentation , prednisone , dystrophy , gastroenterology , pathology , disease , psychiatry
SUMMARY A 62‐year‐old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign multinodular goitre. Hormonal investigations showed no abnormality and no underlying malignancy was found. Investigation of the diarrhoea showed a protein‐losing enteropathy with generalized intestinal polyposis and non‐specific histology. A diagnosis of Cronkhite–Canada syndrome was made. Treatment with prednisone and nutritional support has been partially effective.