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Histopathological evolution of a cutaneous myxofibrosarcoma
Author(s) -
Kwong Rhonda A,
Kossard Steven
Publication year - 2008
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2008.00461.x
Subject(s) - myxofibrosarcoma , medicine , pathology , histopathology , necrobiosis lipoidica , granuloma annulare , histiocyte , giant cell , biopsy , panniculitis , dermatopathology , granuloma , epithelioid cell , sarcoma , dermatology , immunohistochemistry , diabetes mellitus , endocrinology
SUMMARY A 54‐year‐old woman presented with a 6‐month history of a tender and swollen plaque appearing as a panniculitis affecting the left pretibial area. The initial histopathology revealed dermal and subcutaneous inflammation with interstitial histiocytes and mucinosis suggestive of either granuloma annulare or necrobiosis lipoidica. Over the subsequent 6 months the plaque grew progressively, despite treatment with topical corticosteroids under occlusion. Distal to the plaque reduced sensation developed in the limb. Biopsies of the nodular areas now revealed a dense dermal infiltrate of atypical spindle cells within a prominent myxoid stroma and a pleomorphic multinucleated epithelioid cell component. These features were those of an intermediate grade myxofibrosarcoma. This soft‐tissue sarcoma may initially masquerade clinically as a panniculitis and a granulomatous process on biopsy as in our patient, leading to a delay in surgical therapy.