Premium
Aberrant CD8 positive cutaneous T cell lymphomas
Author(s) -
Tallon Ben
Publication year - 2007
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2007.00408_3.x
Subject(s) - mycosis fungoides , medicine , lymphomatoid papulosis , cd30 , pathology , histology , lymphoma , cutaneous lymphoma , cd5 , erythroderma , dermatology
2 cases of unusual CD8 positive cutaneous T cell Lymphoma are presented. A 46 year old woman presents with a five month history of crops of spontaneously resolving crusted papules. Histology shows a wedge shaped lymphocytic infiltrate with marked epidermotropism. The cells were CD30 negative, with CD3, and CD8 positivity. CD56 was strongly represented on cell markers. She has had her lesions controlled on low dose Methotrexate. This CD8 positive CD56 positive type B Lymphomatoid Papulosis followed an indolent clinical course consistent with previous reports. A 72 year old man presents with a 14month history of persistent erythroderma, palmoplantar hyperkeratosis, ectropion and peripheral oedema. Histology shows a lichenoid T cell infiltrate with epidermotropism, Pautrier microabscesses and the presence of cerebriform cells. Immunohistochemistry was positive for CD3 and CD8, with no CD5 drop out, while CD20, CD30 and CD56 were negative. Clinical behaviour and histology of this epidermotropic red man is most consistent with a CD8 positive mycosis fungoides. Aberrant immunohistochemistry can make cutaneous lymphoma classification difficult, but the clinical behaviour is predictive.