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A 30‐year history of CD4+ vesiculo‐bullous mycosis fungoides and multiple visceral malignancies
Author(s) -
Pearce Annette,
Reid Catherine,
Gramp Amanda,
Sidhu Shireen
Publication year - 2007
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2007.00333.x
Subject(s) - mycosis fungoides , medicine , dermatology , pathology , peripheral t cell lymphoma , biopsy , erythroderma , lymphoma , cutaneous t cell lymphoma , skin biopsy , family history , t cell , immunology , immune system
SUMMARY An 83‐year‐old Caucasian woman presented with a 25‐year history of an itchy, eczematous blistering eruption affecting her trunk and acral sites. She had a past history of adenocarcinoma of the lung, colorectal carcinoma and bladder carcinoma. Several skin biopsies consistently showed features of a spongiotic process. Direct and indirect immunofluorescence studies were repeatedly negative, excluding the possibility of an autoimmune blistering disorder. A skin biopsy several years later, however, showed histological and immunophenotypic features of mycosis fungoides. The literature on this rare phenotype of cutaneous T‐cell lymphoma generally portrays a negative prognosis. Our case illustrates an excellent prognosis with stable disease 30 years after onset.