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Abdominal wall ulceration and mucinosis secondary to recombinant human interferon‐β‐1b
Author(s) -
Wells Jillian,
Kossard Steven,
McGrath Michael
Publication year - 2005
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2005.00181.x
Subject(s) - medicine , erythema , heparinoid , mucinosis , dermatology , skin biopsy , abdomen , skin ulcer , interferon , biopsy , abdominal wall , surgery , heparin , pathology , immunology
SUMMARY A 46‐year‐old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon β‐1b subcutaneously for multiple sclerosis. Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis. Treatment with low‐molecular‐weight heparin followed by a heparinoid resulted in slow healing of the ulcers but also allowed the subcutaneous interferon injections to be continued.