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Case of recalcitrant necrobiotic xanthogranuloma
Author(s) -
Wells Jillian,
Gillespie Rod,
Zardawi Ibrahim
Publication year - 2004
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2004.00099.x
Subject(s) - medicine , chlorambucil , melphalan , cyclophosphamide , prednisone , pathological , dermatology , pathology , chemotherapy , surgery
SUMMARY A 53‐year‐old woman with necrobiotic xanthogranuloma presented as infiltrated eyelid plaques, with later development of arm and thigh lesions. Clinical features, including association with immunoglobulin G‐κ paraprotein, and pathological findings were typical of this disorder. Treatment for 15 months with varying combinations of prednisone and multiple chemotherapeutic agents (melphalan, cyclophosphamide and chlorambucil) has led to minimal or no improvement in the clinical lesions or paraprotein. The case demonstrates some of the difficulties in managing this unusual disorder.