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Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: Two cases demonstrating remission with treatment of gynaecological malignancy
Author(s) -
Chamberlain Alexander J,
Cooper Susan M,
Allen Jill,
Dean Diane,
Baxter Kay F,
Goodfield Mark JD,
Wojnarowska Fenella
Publication year - 2004
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2004.00068.x
Subject(s) - epidermolysis bullosa acquisita , medicine , mucocutaneous zone , dermatology , bullous pemphigoid , epidermolysis bullosa , malignancy , immunopathology , ovarian carcinoma , pathology , disease , ovarian cancer , antibody , cancer , immunology
SUMMARY Two cases of paraneoplastic immunobullous disease occurring in women with gynaecological malignancies are reported. Both cases demonstrated mechanobullous mucocutaneous blistering as is typically seen in epidermolysis bullosa acquisita. Their immunopathology, however, favoured a dermal‐binding mucous membrane pemphigoid (MMP) (or possibly bullous pemphigoid) for patient 1 and laminin‐5 MMP for patient 2. Both patients showed resolution of blistering within 1 year of treatment of their malignancies; uterine and ovarian carcinoma, respectively. These cases are of interest because of their paraneoplastic nature; as well as overlapping clinicoimmunopathological features. In addition, patient 2 is, as far as we are aware, the first report of ovarian‐carcinoma‐associated laminin‐5 MMP.