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Healing of severe ulcerative necrobiosis lipoidica with cyclosporin
Author(s) -
Stanway Amy,
Rademaker Marius,
Newman Paul
Publication year - 2004
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2004.00059.x
Subject(s) - necrobiosis lipoidica , medicine , dermatology , ciclosporin , cyclosporins , surgery , chemotherapy , diabetes mellitus , transplantation , endocrinology
SUMMARY A 55‐year‐old woman with severe, chronic, treatment‐resistant ulcerating necrobiosis lipoidica of the shins was commenced on oral cyclosporin at a dose of 2.5 mg/kg/day. Improvement started within 1 week of commencing treatment, and the lesions healed completely over 8 months. Further ulceration occurred 3 months after discontinuing cyclosporin, with improvement on reintroduction of cyclosporin. There have been four previous case reports of healing of treatment‐resistant ulcerating necrobiosis lipoidica with cyclosporin.