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Granular cell basal cell carcinoma
Author(s) -
Dundr Pavel,
Štork Jiří,
Povýšil Ctibor,
Vosmík František
Publication year - 2004
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.2004.00034.x
Subject(s) - cytokeratin , pathology , basal cell carcinoma , medicine , immunohistochemistry , cd68 , lesion , monoclonal antibody , nose , cytoplasm , carcinoma , antibody , basal cell , biology , anatomy , immunology , microbiology and biotechnology
SUMMARY A 69‐year‐old woman presented with a 2‐year history of a slowly growing tumour on the nose. The clinical diagnosis was basal cell carcinoma (BCC) and a complete excision was performed. Histologically, the tumour had the general features of a BCC but with sheets and nests of cells with granular cytoplasmic changes in the centre of the lesion. A pathological diagnosis of granular cell BCC was made. On immunohistochemical examination, the tumour cells were Ber‐EP4, cytokeratin AE1/AE3 and cytokeratin CAM 5.2 positive but S100 protein negative. Only the granular cells were CD68 antigen (monoclonal antibody KP1) positive.