Premium
Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses
Author(s) -
McEwan Lena E,
Smith Jennifer G
Publication year - 1997
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1997.tb01693.x
Subject(s) - medicine , tolerability , hyaluronic acid , diclofenac , dermatology , adverse effect , randomized controlled trial , lesion , complete response , gastroenterology , surgery , anesthesia , chemotherapy , anatomy
SUMMARY A randomized double‐blind controlled trial of 130 patients was performed to study the efficacy and tolerability of topical 3% diclofenac in 2.5% hyaluronic acid (HA) gel (active) versus gel containing 2.5% HA alone (control) in the treatment of solar keratoses. Patients were asked to apply trial gel to the target lesion twice a day and also sunscreen once a day for 24 weeks. The complete response rates were 29% for the active gel and 17% for the control gel. The difference was not statistically significant ( P = 0.14). A high percentage of patients in both groups experienced a partial response to treatment (38% active, 45% control) but there was no significant difference in the spectrum of response between the two treatments ( P = 0.18). Local adverse reactions occurred significantly more frequently in patients using the active gel (29% compared to 5% using control gel, P = 0.0002).