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Immune response to Streptococcus pyogenes and the susceptibility to psoriasis
Author(s) -
Muto Masahiko,
Fujikura Yoshihisa,
Hamamoto Yoshiaki,
Ichimiya Makoto,
Ohmura Akiko,
Sasazuki Takehiko,
Fukumoto Tetsuo,
Asagami Chidori
Publication year - 1996
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1996.tb01087.x
Subject(s) - psoriasis , streptococcus pyogenes , medicine , immune system , immunology , antigen , exacerbation , antibody , streptococcus , monoclonal antibody , biology , bacteria , genetics , staphylococcus aureus
SUMMARY Monoclonal antibodies directed against type 12 Group A streptococcal cell wall antigens cross‐react with nuclei and cytoplasm of cells from skin and synovium from controls, uninvolved skin of psoriatics and psoriatic plaques. Patients with psoriasis had high serum titres of antibody against the M12 (C‐region) streptococcal antigen compared to controls. An abnormal immune response directed against a ‘self’ antigen after initiation by Group A streptococcal infection may play an important role in the exacerbation or development of psoriasis.