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Psoriasis: Mechanisms and entry points for possible therapeutic interventions
Author(s) -
Christophers Enno
Publication year - 1996
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1996.tb01080.x
Subject(s) - psoriasis , medicine , diphtheria toxin , tumor necrosis factor alpha , psoriasis area and severity index , immunology , fusion protein , receptor , toxin , biology , gene , recombinant dna , biochemistry
SUMMARY Psoriasis is a heterogeneous disorder not only in regard to its variability in clinical expression and age at onset, but also in the degree to which genetic and immunological factors such as T cells and cytokines contribute. A ‘Psoriasis Treatment Index’ is proposed according to clinical severity and hence suggested treatment regimens. Recent and new treatments include FK 506, cyclosporin, a fusion protein of human interleukin 2 with fragments of diphtheria toxin, topical tumour necrosis factor inhibitors, topical retinoids, T cell receptor peptide vaccines and intercellular adhesion molecule 1 (ICAM‐1) antisense oligonucleotides.