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Vesiculobullous Hailey‐Hailey disease: Successful treatment with oral retinoids
Author(s) -
Hunt Michelle J,
Salisbury Elizabeth LC,
Painter Dorothy M,
Lee Stephen
Publication year - 1996
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1996.tb01053.x
Subject(s) - medicine , hailey–hailey disease , dapsone , etretinate , dermatology , prednisone , pemphigus , disease , surgery , pathology , psoriasis
SUMMARY A 56‐year‐old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey‐Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey‐Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with lowdose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks.