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CYCLOSPORINE, AZATHIOPRINE AND LOCAL THERAPY FOR PYODERMA GANGRENOSUM
Author(s) -
Duffill Mark B.
Publication year - 1994
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1994.tb01793.x
Subject(s) - medicine , pyoderma gangrenosum , azathioprine , rheumatoid arthritis , triamcinolone acetonide , dermatology , surgery , pyoderma , arthritis , disease
SUMMARY A markedly obese 54 year old woman with seropositive rheumatoid arthritis, anaemia, dyspepsia, controlled hypothroidism and depression presented with a seven month history of large pyoderma gangenosum ulcers on the shins. Routine dressings for the ulcers had been ineffective. Her arthritis was being treated with azathioprine and NSAID's. Initial treatment with clobestasol proprionate and disodium cromoglycate under occlusion produced only partial healing. Introduction of Cyclosporin A and continuation of topical therapy, with the addition of triamcinolone acetonide injections, led to progressive healing which was complete after seven months. There has been no relapse to date. Cyclosporine can be combined with azathioprine and local therapy for successful treatment of pyoderma gangrenosum.