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FIBRONECTIN: STRUCTURE, FUNCTION AND SIGNIFICANCE IN WOUND HEALING
Author(s) -
Brotchie Heather,
Wakefield Denis
Publication year - 1990
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1990.tb00650.x
Subject(s) - medicine , wound healing , fibronectin , microbiology and biotechnology , surgery , extracellular matrix , biology
S ummary Several recent reports suggest a therapeutic role for topical application of autologous fibronectin in promoting healing of chronic skin and corneal ulcers. Fibronectin assists in wound healing by contributing to haemostasis, assisting in control of infection and debridement of wounds, and promoting re‐epithelialisation, granulation tissue and ultimately a connective tissue of adequate tensile strength to repair the skin defect. The potential for fibronectin to be a therapeutic adjunct demands a close understanding of its structural and functional properties, and such knowledge, particularly emerging from research reported in the last five years, is reviewed.