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PROLIFERATION OF HIV IN LYMPHOCYTE – ASSOCIATED MACROPHAGES WITH CYTOPATHIC CHANGES IN AIDS ERYTHRODERMA.
Author(s) -
Heng Madalene C.Y.,
Lambertus Mark,
Goetz Matthew B.
Publication year - 1990
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1990.tb00649.x
Subject(s) - macrophage , in vivo , virus , immunology , virology , in vitro , lymphocyte , medicine , biology , biochemistry , microbiology and biotechnology
S ummary Latency of the Human Immunodeficiency Virus (HIV) has been demonstrated in both helper T‐Lymphocytes and cells of the macrophage/monocyte series. Although mitogendependent amplification of HIV infection within lymphocytes and monocytes/ macrophages has been demonstrated to occur in vitro, in vivo evidence of such a phenomenon has been lacking. We have performed electron microscopic and immunocytochemical evaluation of skin biopsies from a patient with the Acquired Immunodeficiency Syndrome (AIDS) with chronic erythroderma. These biopsies provided evidence of proliferation of HIV in macrophages interacting with activated lymphocytes (CD3+). These macrophages were undergoing morphologic changes characteristic of cytopathicity and contained numerous viral particles, many of which were actively budding from plasma membranes. Cutaneous macrophages which were not interacting with lymphocytes did not demonstrate cytopathicity or evidence of viral multiplication. These in vivo data substantiate the concept that activation of cells which harbour latent HIV promotes viral replication as well as subsequent cytopathicity.