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MULTICENTRIC RETICULOHISTIOCYTOSIS: A LIGHT AND ELECTRON MICROSCOPIC STUDY
Author(s) -
Heenan Peter J.,
Quirk Christopher J.,
Spagnolo Dominic V.
Publication year - 1983
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1983.tb00268.x
Subject(s) - medicine , chlorambucil , pathology , histiocyte , invagination , giant cell , dermatology , anatomy , surgery , chemotherapy , cyclophosphamide
S ummary Multicentric reticulohistiocytosis (MR) with typical skin lesions and arthritis developed in a 51 year old woman. The cutaneous papules and nodules contained a dermal infiltrate of histiocytes and giant cells with ground‐glass cytoplasm. Invagination of elastin and collagen by MR cells was demonstrated by both light and electron microscopy. The patient responded well to treatment with chlorambucil but was subsequently found to have a rapidly disseminating carcinoma of the breast.