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TREATMENT OF CUTANEOUS CANDIDIASIS: A DOUBLE BLIND, PARALLEL COMPARISON OF SULCONAZOLE NITRATE 1% CREAM AND CLOTRIMAZOLE 1% CREAM
Author(s) -
Rajan V. S.,
Thirumoorthy T.
Publication year - 1983
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1983.tb00245.x
Subject(s) - clotrimazole , medicine , double blind , significant difference , adverse effect , dermatology , surgery , antifungal , pathology , alternative medicine , placebo
S ummary Fifty‐seven subjects with clinically proven cutaneous candidiasis were entered into a double blind, parallel, randomized comparison of sulconazole nitrate 1 % cream applied once daily and clotrimazole 1% cream applied twice daily. The duration of active treatment was three weeks with a four‐week follow‐up without treatment for those clinically cured at Week 3 to determine relapse rate. Sixteen patients failed to complete the study, twelve for reasons unrelated to study medication and four with suspected adverse reactions to sulconazole nitrate. There were no statistically significant differences between the two treatments when considering efficacy parameters (which included KOH microscopic preparation, fungal culture and clinical evidence of fungal infection). There were seven sulconazole nitrate and three clotrimazole treatment failures (ascertained by positive KOH microscopic preparation) at Week 3, this difference not being statistically significant. There were no relapses at the four‐week follow‐up in patients clinically cured after three weeks active treatment.