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LUPUS BAND AND ORGANIZED FINGER‐PRINT DEPOSITS
Author(s) -
Adam B. A.
Publication year - 1982
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1982.tb00742.x
Subject(s) - medicine , dermatology , systemic lupus erythematosus , pathology , disease
S ummary Immunoelectron microscopical examination with peroxidase labelled anti‐human IgG of the lesional skin in discoid lupus erythematosus showed an abundance of extracellular organized finger‐print deposits (OD) in the papillary dermis, probably contributing to the lupus band seen in direct immunofluorescence test. The OD is probably an immunoglobulin but its assembly as seen in the ultra thin section does not resemble known arrangements of protein subunits. Its spatial arrangement may be due to a membrane‐like structure rather than a three‐dimensional tubular configuration. Fine granular densities found together with OD are either additional immune reactants or degraded OD. In the deeper dermis these deposits, probably in the process of degradation, were found within the secondary lysosomes of the dermal macrophages. The significance of OD in the diagnosis of lupus erythematosus needs further confirmation.