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BIPHASIC AMYLOIDOSIS: A CLINICOPATHOLOGICAL AND HISTOCHEMICAL STUDY *
Author(s) -
Nakjang Y. S.,
Sivavathorn A.,
Reungsinpinya S.,
Yutthanawiwat T.
Publication year - 1982
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1982.tb00607.x
Subject(s) - medicine , amyloidosis , pathology , eosinophilic , amyloid (mycology) , dermis , anatomy , dermatology
S ummary A study of 64 patients with biphasic amyloidosis revealed the usual clinical features‐discrete, lichenified flesh‐coloured to brownish papules and brown rippled macules. Areas involved included (he shins, thighs, waist, upper back, arms and face. Two patients had tense bullae overlying cutaneous amyloidosis lesions. Characteristic histopathological features of biphasic amyloidosis included circumscribed homogenous eosinophilic masses of amyloid in the upper dermis closed to the epidermis. Small fissures above amyloid masses could often be seen in papular lesions. Large subepidermal bullae with PAS positive basement membrane at the floor of bullae were seen in cases of biphasic amyloidosis with tense bullae. Elastic and reticulum fibres were usually markedly decreased or absent.