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ROLE OF LYMPHOCYTE TRANSFORMATION IN DRUG ALLERGY *
Author(s) -
Sarkany I.,
Gaylarde P. M.
Publication year - 1978
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1978.tb00189.x
Subject(s) - medicine , drug allergy , drug , immunology , promethazine , in vivo , hepatitis , pharmacology , lymphocyte , cytotoxic t cell , griseofulvin , allergy , in vitro , virology , pathology , biology , biochemistry , microbiology and biotechnology
S ummary The role of lymphocyte transformation in the diagnosis of drug allergy is reviewed. Of 165 patients with clinically suspected drug allergy, 22 (13.3%) gave a positive lymphocyte transformation result. Reasons for this low incidence of positive reactions are put forward. Lymphocyte transformation testing in patients with halothane related hepatitis was uniformly negative in 29 patients and this test has not been found useful in the diagnosis of this condition as against viral hepatitis. We have also found that a number of drugs including co‐trimoxazole, piperazine, chlorpromazine, promethazine and griseofulvin inhibit DNA synthesis in lymphocytes in vitro. This may be the result of inhibition of transformation of lymphocytes, a cytotoxic effect or the effect of inhibition of thymidine incorporation. The in vitro suppression of DNA synthesis in lymphocytes by co‐trimoxazole, rifampicin and miconazole has been suggested as being related to their possible in vivo immunosuppressive activity.