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MELANOMA SPECIFIC PROTEIN: DETECTION AND CHARACTERIZATION OF A TUMOUR SPECIFIC PROTEIN FROM MELANOTIC URINE *
Author(s) -
Bennett Claire,
Cooke K. Brian
Publication year - 1978
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1978.tb00180.x
Subject(s) - urine , melanoma , medicine , antiserum , pathology , microbiology and biotechnology , staining , cytoplasm , cancer research , antibody , biology , immunology , biochemistry
S ummary Urine from patients with malignant melanoma contains a specific protein not detected in normal urine nor in the urine of any other cancer patients tested. This protein is also found in urine from patients with actively developing halo naevi. It is detected by its ability to inhibit the cytoplasmic staining of malignant melanoma cells by rabbit antimelanoma antisera. The protein is sialo‐protein, molecular weight 76,000 daltons, with α1 globulin mobility. It is suggested that it may be related to the melanosomal proteins.