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Experimental Investigations on Interactions between Gentamicin and Betamethasone Dipropionate
Author(s) -
Raab Wolfgang
Publication year - 1973
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1973.tb00706.x
Subject(s) - gentamicin , betamethasone , medicine , betamethasone dipropionate , potency , pharmacology , antibiotics , in vivo , glucocorticoid , corticosteroid , microbiology and biotechnology , in vitro , chemistry , biology , biochemistry
SUMMARY As a model for recommendable investigations in combined drug therapy, experiments on possible interactions between a modern glucocorticold (betamethasone 17,21 dipropionate) and an antibacterial antibiotic (genta‐micin) were performed. On resting and proliferating bacteria (staphylococci, pseudomonas), the antibacterial efficacy of gentamicin was not imparired in the presence of betamethasone dipropionate in “activating” concentrations, which means that the glucocorticoid itself, in the concentration used for the experiments, enhanced bacterial metabolism. The topical potency of the glucocorticoid was measured by vasoconstrictor assay; in low concentrations (0.001% to remained practically unchanged in the presence of gentamicin in a twenty‐fold concentration as applied clinically. It was concluded from these experimental in vitro and in vivo studies that betamethasone dipropionate and gentamicin may safely be used together, without the risk of unwanted interactions.